Biosynthesis of ergotamine
نویسندگان
چکیده
منابع مشابه
Biosynthesis of ergotamine by Claviceps purpurea (Fr.) Tul.
High-yielding strains of Claviceps purpurea (Fr.) Tul, grown on a defined medium, have been used for a study of the biosynthesis of the peptide ergot alkaloid, ergotamine. l-[U-(14)C]tryptophan, dl-[2-(14)C]mevalonic acid lactone, sodium [2-(14)C]acetate, sodium [(14)C]formate and the methyl group of l-[methyl-(14)C]methionine were efficiently incorporated into the peptide alkaloids and specifi...
متن کاملBuccal absorption of ergotamine.
The rate of disappearance of ergotamine from the mouth after buccal administration has been studied in seven subjects. Allowance has been made for non-absorptive losses of the drug due to experimental technique. The absorption of ergotamine across the buccal mucosa appears to be a passive process, pH-dependent but independent of ergotamine concentration or the simultaneous presence of caffeine....
متن کاملErgotamine absorption and toxicity.
Adverse reactions to ergotamine were noted in 16 out of 41 studies in which therapeutic doses of the drug were given to normal, healthy volunteers. In 17 of the studies 0.25 mg ergotamine was given by injection, 6 i.v. and 11 i.m., in 20 studies 2 mg ergotamine was given by mouth, and 4 subjects received 2 mg ergotamine by suppository. Plasma and urinary ergotamine was measured by radio-immunoa...
متن کاملErgotamine and cerebral blood flow.
We measured the cerebral blood flow (CBF) of 16 patients by the xenon-133 intracarotid method before and after the intramuscular injection of ergotamine tartrate. The regional and hemispheric CBF was unaltered, even in 3 migraneurs in who ergotamine relieved the headache. Ergotamine tartrate in therapeutic doses has no effect on the cerebral circulation.
متن کاملErgotamine-induced venous thrombosis.
but levels of up to 6 mg%0 have been recorded (Lous, 1954). Undoubtedly, acute barbiturate toxicity is associated with the development of neurological signs, such as depressed tendon reflexes and extensor plantar responses (Carroll, 1969) but it is of interest that both patients showed these changes without gross respiratory or cardiovascular depression. Following recovery from coma, both patie...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1220058pb